Agmatine administration effects on equine gastric ulceration and lameness

Glandular mucosal ulcer scores were lower after agmatine than phenylbutazone administration

Osteoarthritis (OA) accounts for up to 60% of equine lameness. Agmatine, a decarboxylated arginine, may be a viable option for OA management, based on reports of its analgesic properties. Six adult thoroughbred horses, with lameness attributable to thoracic limb OA, received either daily oral phenylbutazone (6.6 mg/kg), agmatine sulfate (25 mg/kg) or a control for 30 days, with 21-day washout periods between treatments. Subjective lameness, thoracic limb ground reaction forces (GRF), plasma agmatine and agmatine metabolite levels were evaluated using an established rubric, a force platform, and mass spectrometry, respectively, before, during and after each treatment period. Gastric ulceration and ...

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MICHELE TUMBARELLO, Med Vet, PhD Anesthesiology 13 February 2023

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Agmatine administration effects on equine gastric ulceration and lameness

Scientific Publishing

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Agmatine administration effects on equine gastric ulceration and lameness

Scientific Publishing