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Lipofuscin-like cytoplasmic inclusions in canine blood leukocyte

Lipofuscin-like cytoplasmic inclusions in canine blood leukocyte
  • These inclusions revealed a severe hepatocellular involvement

Lipofuscin-like cytoplasmic inclusions have been reported in human blood neutrophils and monocytes but have not been described in dogs. In people, these "green granules of death" have been associated with moderate to severe hepatocellular injury and high mortality. The major goal of this study was to describe clinicopathologic abnormalities, diagnoses, and outcomes of dogs with greenish inclusions in blood neutrophils or monocytes, and to determine if the inclusions have features of lipofuscin. Clinical cases were identified prospectively through routine evaluation of CBC samples. Leukocyte inclusions were characterized with routine staining and assessed for iron and autofluorescence. Additional cases were identified by ...

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