Acromegaly in humans and cats: resemblances and differences

Acromegaly is a disorder associated with excessive growth hormone (GH) levels and insulin-like growth factor-1 (IGF-1). In general, GH/IGF-1 excess leads to morphologic craniofacial and acral changes and cardiometabolic complications, but the phenotypic changes and clinical presentation of acromegaly differ across species. Here, the authors reviewed the pathophysiology, clinical presentation, and management of acromegaly in humans and cats, and we systematically compare this disease across these different species. A comprehensive literature review of pathophysiology, clinical features, diagnosis, and management of acromegaly in humans and cats was performed. Acromegaly is associated with prominent craniofacial changes in both species: frontal bossing, enlarged ...

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