Hypothalamic-pituitary-adrenal axis recovery after glucocorticoid treatment in dogs

In dogs, duration of hypothalamic-pituitary-adrenal (HPA) axis suppression after systemic glucocorticoid (GC) treatment is reported to vary from a few days to up to 7 weeks after glucocorticoid discontinuation. These data are derived mainly from experimental studies in healthy dogs and not from animals with spontaneous disease. This single-center prospective observational study aimed to determine the timeline for recovery of the HPA axis in a group of ill dogs treated with systemic intermediate-acting glucocorticoids (IAGCs) Dogs that received IAGC for at least 1 week were included. An ACTH stimulation test, endogenous ACTH concentration, serum biochemistry profile, and urinalysis were performed at ...

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