Fibroblast growth factor 19 concentrations in dogs with gallbladder mucoceles

Authors hypothesized that serum FGF19 concentrations may be low in dogs with clinical gallbladder mucoceles

Fibroblast growth factor 19 (FGF19) is an enterohepatic hormone the synthesis of which is stimulated by bile acid activation of the nuclear farnesoid X receptor (FXR) in ileal enterocytes. Increased production of FGF19 downregulates hepatocyte bile acid synthesis and gluconeogenesis, while concurrently upregulating hepatocyte glycogenesis and gallbladder (GB) filling. The physiologic impact of this regulatory cycle is illustrated in cholecystectomized humans, in whom the disturbed meal-related flux of GB bile decreases serum FGF19 concentrations. This study aimed to determine if serum FGF19 concentrations are lower in dogs with clinical GB mucoceles (GBMs) than in control dogs. Seven dogs with GBM diagnosed ...

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MICHELE TUMBARELLO, Med Vet, PhD Gastroenterology 09 September 2024

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Fibroblast growth factor 19 concentrations in dogs with gallbladder mucoceles

Scientific Publishing

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Fibroblast growth factor 19 concentrations in dogs with gallbladder mucoceles

Scientific Publishing