Carboxyhemoglobin as a diagnostic biomarker of hemolytic anemias in dogs

Endogenous production of carbon monoxide during hemoglobin metabolism leads to the formation of carboxyhemoglobin. Carboxyhemoglobin concentration is abnormally high in humans with hemolytic anemia (HA). The hypothesis of the authors of this prospective cohort study was that the measurement of carboxyhemoglobin concentration can discriminate HA from other forms of anemia. Carboxyhemoglobin quantification, a CBC and biochemistry profile were performed upon admission, and survival to hospital discharge and at 30 days were the measured outcomes. Groups were compared by the Mann-Whitney and Kruskal-Wallis tests. Receiver-operator characteristic (ROC) analyses were used to examine the predictive utility of carboxyhemoglobin for the diagnosis of HA ...

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