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CONTINUING SCIENTIFIC EDUCATION IN VETERINARY MEDICINE

Monday, 14 November 2022

Inflammatory markers in the equine insulin dysregulation

  • Proinflammatory cytokines were upregulated in adipose tissue
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equine metab syndromeSimilar to human diabetes, equine metabolic syndrome (EMS) causes insulin dysregulation leading to debilitating sequela including laminitis. The pathophysiological mechanisms underlying EMS and laminitis are not well known. Therefore, using an insulin-resistant equine model, the authors hypothesized that insulin dysregulation induces an increased expression of inflammatory proteins in a tissue specific manner. 

Two groups of horses (n = -5/group) were categorized as insulin-resistant (IR) or insulin-sensitive (IS), using a frequently sampled intra-venous glucose tolerance test. Biopsies from skeletal muscle, and visceral and subcutaneous adipose tissues were collected in both groups. Protein expression was quantified via Western blotting in order to investigate HSP90, α 2 macroglobulin (A2M), Fibrinogen α, β, γ isoforms as well as cytokines, including interleukin-1β (IL-1β) and interleukin-6 (IL-6), in muscle and adipose tissues. 

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Written by
Michele Tumbarello Med Vet PhD student

Read 27 times Last modified on Wednesday, 16 November 2022 12:27

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