Monday, 19 December 2022 Written by Antonio Maria Tardo Med Vet PhD Student
- This is the first reported case of congenital hyperinsulinism in a cat
A 5.5 month-old intact male Maine Coon cat was presented to a referral hospital for a history of muscle fasciculations, lethargy and seizures associated with refractory hypoglycemia. Diagnostic testing for hypothyroidism, hyposomatotropism or hypoadrenocorticism, inborn errors of metabolism (ie, storage diseases and urea cycle disorders), infection or iatrogenic hypoglycemia were negative. An inappropriately high serum insulin level was noted in the ...
Monday, 14 November 2022 Written by Michele Tumbarello Med Vet PhD student
- Proinflammatory cytokines were upregulated in adipose tissue
Similar to human diabetes, equine metabolic syndrome (EMS) causes insulin dysregulation leading to debilitating sequela including laminitis. The pathophysiological mechanisms underlying EMS and laminitis are not well known. Therefore, using an insulin-resistant equine model, the authors hypothesized that insulin dysregulation induces an increased expression of inflammatory proteins in a tissue specific manner. Two groups of horses (n = -5/group) were ...
Monday, 10 October 2022 Written by Antonio Maria Tardo Med Vet PhD Student
- Plasma ACTH concentrations were higher in septic and premature foals on admission compared to healthy controls
Sepsis is a major cause of morbidity and mortality in neonatal foals. Relative adrenal insufficiency (RAI), defined as an inadequate cortisol response to stress, has been associated with sepsis, prematurity, and poor outcome in newborn foals. In addition to cortisol, the adrenal gland synthesizes several biologically important steroids and steroid precursors, including aldosterone, androgens, and progestogens. However, concentration of these hormones du...