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CONTINUING SCIENTIFIC EDUCATION IN VETERINARY MEDICINE

Pharmacology

Pharmacology (1)

Monday, 21 November 2022

Canine and feline P-glycoprotein deficiency

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  • The so-called "ivermectin sensitivity" was determined to be a P-glycoprotein deficiency caused by a genetic variant of the MDR1
image assetIn 2001 the molecular genetic basis of so-called "ivermectin sensitivity" in herding breed dogs was determined to be a P-glycoprotein deficiency caused by a genetic variant of the MDR1 (ABCB1) gene often called "the MDR1 mutation." We have learned a great deal about P-glycoprotein's role in drug disposition since that discovery, namely that P-glycoprotein transports many more drugs than just macrocyclic lactones that P-glycoprotein mediated drug transport i...

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