Nephrology-Urology (7)
Monday, 30 January 2023
Risk factors of enterococcal bacteriuria in cats
Written by Michele Tumbarello Med Vet PhD student- Urothelial damage and inflammation may not be the mechanism for enterococcal bacteriuria in cats
The purpose of this study was to determine if factors associated with urothelial damage and inflammation, including urinary catheterization, urinary obstruction, and urolithiasis are associated with the presence of enterococcal bacteriuria in cats.A retrospective case-control study with cases and controls identified by records search for Enterococcus spp. (case) and E. coli (control) bacteriuria from August 1, 2014 to July 31, 2019. Cases and controls were balance...
Monday, 16 January 2023
Prevalence of Bacterial Uropathogens Isolated from Dogs and Cats
Written by Michele Tumbarello Med Vet PhD student- E. coli was the most frequently isolated pathogen
Bacterial urinary tract infection (UTI) is a common diagnosis in companion animal practice and is one of the leading reasons for antimicrobial prescriptions. The authors analysed 1862 samples from the urinary tract of dogs and cats, submitted to a veterinary microbiological diagnostic laboratory in 2019 and 2020 in Germany. Susceptibility of 962 uropathogenic isolates to 15 antimicrobials, suggested as first- and second-line treatment options for UTI,...
Monday, 12 December 2022
Serum uromodulin concentration in dogs with chronic kidney disease
Written by Michele Tumbarello Med Vet PhD student- There was a negative correlation between uromodulin concentration and conventional renal markers
Serum uromodulin concentration has been described as a novel biomarker of chronic kidney disease (CKD) in humans but not dogs. The aim of this study was to evaluate the serum uromodulin concentration in dogs with CKD and assess its diagnostic performance in distinguishing dogs with CKD from healthy dogs.Serum uromodulin concentration was measured using a canine-specific enzyme-linked immunosorbent assay (ELISA), and its correlation with conventional renal markers was analyzed....
Wednesday, 07 December 2022
Serum and urine biomarkers in cats with interstitial and bacterial cystitis
Written by Michele Tumbarello Med Vet PhD student- Serum NGF is a candidate biomarker that could be used in the diagnosis of FIC
Although feline urine is increasingly submitted for bacterial culture and susceptibility testing in veterinary practice, bacterial cystitis (BC) is relatively uncommon compared with feline interstitial cystitis (FIC), which shares similar clinical manifestations. Therefore, an investigation of certain urothelial (glycosaminoglycan [GAG], tissue inhibition metalloproteinase-2 [TIMP-2]), cytokine (interleukin 12 [IL-12]), and neurotrophic factor (nerve growth factor [NGF]) markers ...
Friday, 25 November 2022
Use of urinalysis during baseline diagnostics in dogs and cats
Written by Antonio Maria Tardo Med Vet PhD Student- Participants performed urinalyses much less frequently than blood work during a routine examination
The aim of this study was to describe how veterinarians utilise and perform urinalyses for dogs and cats.A survey, developed and distributed through the Veterinary Information Network, enlisted veterinarians who perform urinalyses for dogs and cats. Participants were directed to question banks based on whether urinalyses were performed in-house, by an outside diagnostic laboratory, or using an in-house automated instrument. Participants using mult...
Wednesday, 19 October 2022
Biomarkers of Kidney Disease in Horses
Written by Antonio Maria Tardo Med Vet PhD Student- There are multiple new biomarkers with the potential to diagnose kidney problems
Creatinine only allows detection of kidney disease when 60 to 75% of the glomerular function is lost and is therefore not an ideal marker of disease. Additional biomarkers could be beneficial to assess kidney function and disease. The objectives are to describe new equine kidney biomarkers.This systematic review assesses the available literature, including the validation process and reference values, following which...
Wednesday, 12 October 2022
Effect of pimobendan on renal function in dogs with MMVD
Written by Michele Tumbarello Med Vet PhD student- Pimobendan might not affect renal function in nonazotemic, B2 MMVD dogs
Pimobendan might have favorable effects on renal function, but this has not been well-studied in dogs with myxomatous mitral valve disease (MMVD). The aim of the study was to determine the effects of standard-dose (SD_pimo) and high-dose pimobendan (HD_pimo) on glomerular filtration rate (GFR) and cardiac size and function in dogs with preclinical MMVD.... 
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