Common variable immunodeficiency in horses

The clinical manifestation of recurrent fevers and infections alerts the clinician to the possibility of an underlying immunodeficiency. Common variable immunodeficiency (CVID) in the horse is a rare late-onset, nonfamilial immunological disorder of B cell depletion and/or dysfunction with resultant inadequate antibody production. This article describes the clinical and immunological findings in 100 equine cases, and comparisons with the disease in human patients. The most common clinical presentations in horses with CVID are recurrent upper and/or lower respiratory infections, meningitis and/or ataxia, cholangiohepatitis, infectious colitis, infectious dermatitis and severe gastrointestinal parasitism. Immune-mediated and lymphoproliferative conditions are additional clinical features. The diagnosis ...

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