Renal candidiasis in a captive tiger

A 14-year-old male tiger developed anorexia with elevated blood urea nitrogen and creatinine levels. The patient had a palpable abdominal mass and demonstrated neutrophilic leukocytosis and anemia. Leukocytes, yeast, and bacteria were present in the urine. The animal was non-responsive to therapy and was subsequently euthanized. Extensive acute renal papillary necrosis (RPN) with pyelonephritis, chronic nephritis, and polycystic renal disease were evident during gross and microscopic pathology examinations. The histologic occurrence of fungal spores and pseudohyphae morphologically consistent with Candida species was observed within the necrotic papillary regions of the kidney and multiple foci of mild parakeratotic hyperkeratosis were present ...

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