The renin-angiotensin-aldosterone system in kidney diseases of cats and dogs
Further research of the circulating RAAS, the intrarenal RAS, and the interplay between these systems might contribute to the development of future treatment strategies
The renin-angiotensin-aldosterone system (RAAS) has a well-established key pathophysiologic role in kidney diseases, and pharmacotherapy targeting this system is a mainstay of treatment of affected human beings, cats, and dogs. Several studies have evaluated the circulating RAAS in animals with spontaneous or experimentally induced kidney diseases. Evidence supporting the activation of this system has been demonstrated in some - but not all - studies and individuals, and the interindividual variability in circulating RAAS markers is high.
Advances over the last few decades have expanded our understanding of the system, which now includes the existence of a counterbalancing "alternative" RAAS and tissular ...
To read the full article you must log in with your EGO codes.