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CONTINUING SCIENTIFIC EDUCATION IN VETERINARY MEDICINE

Displaying items by tag: dog

fna dogWhen a solitary liver mass is identified in a dog, a fine-needle aspirate (FNA) is commonly employed to attempt to obtain a diagnosis. Little information is provided in the literature evaluating the sensitivity/specificity of FNA cytology for solitary liver masses. The authors hypothesized that liver lesion size nor the presence of cavitation would impact the success of cytological diagnosis.

Medical records were obtained for 220 client-owned dogs. Inclusion criteria included preoperative abdominal imaging, percutaneous FNA of a solitary hepatic mass with cytologic interpretation by a board-certified pathologist, and a surgical biopsy or mass excision yielding a histopathological diagnosis. 

torascopia caneThe aim of this retrospective study was to report outcomes of thoracoscopic (TL) and thoracoscopic-assisted lung lobectomy (TAL) for treatment of non-neoplastic pulmonary consolidation (PC) in dogs.

The medical records of 12 dogs that underwent TL or TAL for PC at 3 veterinary institutions between 2011 and 2020 were reviewed. Signalment, history, physical examination, diagnostics, days in hospital, anesthetic and procedure times, intraoperative/postoperative complications, conversion rates, duration of indwelling thoracic drain, and long-term outcomes were recorded.

Published in General surgery

anemia emolitica caneEndogenous production of carbon monoxide during hemoglobin metabolism leads to the formation of carboxyhemoglobin. Carboxyhemoglobin concentration is abnormally high in humans with hemolytic anemia (HA). The hypothesis of the authors of this prospective cohort study was that the measurement of carboxyhemoglobin concentration can discriminate HA from other forms of anemia.

Carboxyhemoglobin quantification, a CBC and biochemistry profile were performed upon admission, and survival to hospital discharge and at 30 days were the measured outcomes. Groups were compared by the Mann-Whitney and Kruskal-Wallis tests. Receiver-operator characteristic (ROC) analyses were used to examine the predictive utility of carboxyhemoglobin for the diagnosis of HA in anemic dogs.

Published in Haematology

ipb dogPlatelet indices changes in severely ill people and in dogs with inflammation are compatible findings. This study aimed to compare platelet indices between dogs with clinical benign prostatic hyperplasia (BPH) and healthy controls. Additionally, to determine whether there is a correlation between the relative prostatic size (S rel) and the platelet indices in BPH dogs.

Thirty-five adult intact male dogs of different breeds were allocated to the experimental groups: dogs with clinical BPH (groups A; n = 24; median age of 6 years; the median weight of 8.50 kg) and healthy dogs (group B; n = 11; median age 5.50 years; the median weight of 7.00 kg) based on physical examination, clinical signs, and S rel detected by ultrasonographic findings. The individual prostatic volume (IPV) was divided by the expected prostatic volume (EPV) to determine the relative prostatic size in dogs over 4 years old. Platelet indices were compared between the two groups, and a correlation between S rel and these indices was calculated.

Published in Reproduction

sirs dogSeveral studies performed in humans have demonstrated that the onset of systemic inflammatory response syndrome (SIRS) represents a high risk condition to develop myocardial damage and arrhythmias. Therefore, the authors also hypothesized cardiac involment for dogs affected by SIRS. 

To assess this hypothesis, 24 dogs with a diagnosis of SIRS (13 entire males, 7 entire females, and 4 spayed females) with an age ranging from 4 to 11 years (mean 5.6 years) and an average weight of 24 kg (range from 5 to 47 kg) were enrolled. The dogs were divided into two groups according to their prognosis: Survivors (G1) and not survivors (G2), composed by 13 and 11 dogs, respectively. Moreover, healthy dogs were included as the control group (CTR). All the dogs with a history of cardiac or renal disease were excluded. At the inclusion, each patient underwent a physical examination and a complete cell count, and a biochemistry panel (including electrolyte profile) was performed; moreover, the blood cardiac Troponin I (cTnI) was measured. For each clinical variable indicative of SIRS, a score between 0 (absence) and 1 (presence) was applied. Furthermore, an electrocardiographic examination was recorded. 

Published in Cardiology
Wednesday, 30 November 2022 12:37

Retrospective study of sternal lymphadenopathy in dogs

tc dog sternale linfoSternal lymph nodes (SLNs) drain a multitude of regions in dogs, including the pectoral and shoulder region, the thoracic wall and mammary glands, the mediastinum, thymus, diaphragm, and the ventral abdominal wall and peritoneal cavity. Neoplastic conditions of these regions can lead to sternal lymphadenopathy. The aim of this study was to assess the most frequent localizations of the primary neoplasia and the most frequent tumor types in dogs with sternal lymphadenopathy. 

For this single-center retrospective descriptive study, dogs with sternal lymphadenopathy and cytological or histological diagnosis of neoplasia were included. Computed tomographic (CT) characteristics of SLNs in dogs with confirmed neoplasia were also described.

Published in Diagnostic imaging
Wednesday, 30 November 2022 11:42

Clinical features of canine infective endocarditis

endocardite caneThe aim of this study was to determine the causative organisms, clinical features and outcome of canine infective endocarditis in the UK.

Medical records of three veterinary referral hospitals were searched for dogs with infective endocarditis between December 2009 and December 2019. Signalment, clinical signs, causative organism, valve affected, treatment and survival data were recorded.

dog ckdSerum uromodulin concentration has been described as a novel biomarker of chronic kidney disease (CKD) in humans but not dogs. The aim of this study was to evaluate the serum uromodulin concentration in dogs with CKD and assess its diagnostic performance in distinguishing dogs with CKD from healthy dogs.

Serum uromodulin concentration was measured using a canine-specific enzyme-linked immunosorbent assay (ELISA), and its correlation with conventional renal markers was analyzed.

Published in Nephrology-Urology

tumour immunoregulatoryCancers utilize a variety of molecules to escape host immune responses. Better understanding the immune environment surrounding cancer may facilitate application of innovative cancer immunotherapies, such as immune checkpoint inhibitors, to dogs as well as humans. 

In this study, the authors screened the expression of 20 immune regulatory molecules in diverse canine tumors (n = 59). 

bulldog reflussoThe aim of this prospective, non-randomized study was to evaluate the effect of nine different premedication medications on the incidence of gastroesophageal reflux (GOR) in anesthetized dogs. 

Two hundred and seventy dogs undergoing non-intrathoracic, non-intrabdominal elective surgeries or invasive diagnostic procedures were included in the study and were allocated into nine groups (30 dogs/group) defined by the type of premedication administered. Premedication consisted of dexmedetomidine with either morphine, pethidine or butorphanol, acepromazine with either one of the three opioids or midazolam with one of the above-mentioned opioids. Anesthesia was induced with propofol and maintained with isoflurane in oxygen. Esophageal pH was measured with the use of a pH-meter electrode and a pH-value less than 4 and over 7.5 was considered to be GOR. 

Published in Anesthesiology
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