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Bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia

  • Findings from this study suggest that hematologic and morphologic variables are useful to predict outcomes in myeloid neoplasia

Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are heterogeneous neoplasms of hematopoietic stem cells that are challenging to diagnose, differentiate, and prognosticate. Cytogenetic and mutational analyses are useful in humans but unavailable for dogs, where diagnosis and classification still rely largely on hematologic and morphologic assessment. The objectives of this study were to apply a classification scheme to myeloid neoplasms and to assess outcomes in relation to predictor variables. Keyword search of a laboratory database, application of sequential exclusion criteria, and consensus from 3 reviewers yielded 70 cases of myeloid neoplasia with hematology results and cytologic (11), histologic (14), or ...

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