Leukoreduction in a dog with acute leukemia

This case report discusses a 9-year-old neutered male Golden Retriever crossbreed that was evaluated due to the acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia. Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. Leukoreduction via leukapheresis was elected to reduce the disease burden before initiating chemotherapy. Postleukoreduction, the dog had a 54% decrease in their white blood cell count. The dog completed multiple weeks of traditional cyclophosphamide, ...

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