Vincristine-induced adverse events related to body weight in dogs

To evaluate the frequency of hematologic and gastrointestinal AEs in dogs with newly diagnosed lymphoma treated with vincristine

Traditional dosing of chemotherapy drugs based on body surface area may overdose small dogs, leading to an increased frequency of adverse events (AEs). This study aimed to evaluate the frequency of hematologic and gastrointestinal AEs in dogs with newly diagnosed lymphoma treated with vincristine weighing ≤15 kg in comparison to dogs weighing >15 kg. We hypothesized that dogs weighing ≤15 kg would experience a higher frequency of AEs. One hundred and thirty-eight dogs with newly diagnosed lymphoma treated with vincristine were included. A multicenter retrospective study reviewing hematologic data and medical record information. Complete blood counts were performed no more ...