Comparison of grapiprant and meloxicam for management of postoperative joint pain in dogs

Grapiprant is a novel anti-inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs. This study aimed to compare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs. In this randomized, double-blinded, prospective clinical trial, Forty-eight client-owned dogs presented with cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) were included between May 2020 and May 2022. The day after surgery, all animals received a subcutaneous injection of 0.2 mg/kg of meloxicam and were randomly assigned to receive either oral grapiprant (2 mg/kg) or meloxicam (0.1 mg/kg), once a ...

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