Canine and feline P-glycoprotein deficiency

The so-called "ivermectin sensitivity" was determined to be a P-glycoprotein deficiency caused by a genetic variant of the MDR1

In 2001 the molecular genetic basis of so-called "ivermectin sensitivity" in herding breed dogs was determined to be a P-glycoprotein deficiency caused by a genetic variant of the MDR1 (ABCB1) gene often called "the MDR1 mutation." We have learned a great deal about P-glycoprotein's role in drug disposition since that discovery, namely that P-glycoprotein transports many more drugs than just macrocyclic lactones that P-glycoprotein mediated drug transport is present in more places than just the blood brain barrier, that some cats have a genetic variant of MDR1 that results in P-glycoprotein deficiency, that P-glycoprotein dysfunction can occur as a result ...

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Antonio Maria Tardo Med Vet PhD Pharmacology 21 November 2022

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Canine and feline P-glycoprotein deficiency

Scientific Publishing

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Canine and feline P-glycoprotein deficiency

Scientific Publishing