Pharmacodynamics of 2 dosages of esomeprazole in dogs

Esomeprazole use is increasing in dogs, but the gastrointestinal adverse events associated with q12h dosing necessitate pharmacodynamic evaluation of a reduced dose and frequency of administration. This study aimed to compare the efficacy of 2 doses of (q24h) esomeprazole in raising intragastric pH in dogs. Nine healthy, client-owned dogs, >20 kg were included in this prospective, randomized, double blinded, crossover study. Esomeprazole (0.5 or 1 mg/kg q24h) was orally administered for up to 5 days per treatment arm, and the mean percentage time intragastric pH was ≥3 (MPT3) and ≥4 (MPT4) for 24 hours periods were compared to pretreatment pH using ...

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