Pharmacokinetic analysis of enrofloxacin in cats with reduced kidney function

It is unknown if enrofloxacin accumulates in plasma of cats with reduced kidney function. The aim of this study was to determine if enrofloxacin and its active metabolite ciprofloxacin have reduced clearance in azotemic cats. Thirty-four cats hospitalized for clinical illness with variable degree of kidney function were prospectively included. After enrofloxacin (dose 5 mg/kg) administration to cats, sparse blood sampling was used to obtain 2 compartment population pharmacokinetic results using nonlinear mixed-effects modeling. Plasma enrofloxacin and ciprofloxacin concentrations were measured and summed to obtain the total fluoroquinolone concentration. Body weight was the only covariate found to affect total fluoroquinolone volume of ...

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