Pharmacokinetic of phenylbutazone in horses

The current study objective was to evaluate the effects of aging on phenylbutazone (PBZ) disposition in older horses (≥ 25 years old) compared to young adults (4 to 10 years old) by characterizing the pharmacokinetic profile of PBZ and its active metabolite, oxyphenbutazone (OPBZ), following a 2.2-mg/kg dose, IV. The authors hypothesized that the disposition of PBZ will be affected by age. Sixteen healthy horses (8 young adults aged 4 to 10 years and 8 geriatric horses ≥ 25 years old) were enrolled. Horses were administered a single 2.2-mg/kg PBZ dose, IV. Plasma samples were collected at designated time points and ...

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