Pharmacokinetics of buprenorphine in four-toed hedgehogs

There is little information regarding analgesia in pet hedgehogs. A recent study demonstrated that a single subcutaneous (SC) injection of buprenorphine hydrochloride in four-toed hedgehogs produced antinociception up to 36 to 48 hours, longer than for any other species. The goal of this study was to evaluate the pharmacokinetics of a single, deep SC dose of buprenorphine hydrochloride in four-toed hedgehogs to expand understanding of clinical pharmacokinetics in this popular pet species. Baseline blood samples were collected from the jugular veins of 6 adult hedgehogs under isoflurane anesthesia. Buprenorphine (0.05 mg/kg) was administered into the dorsal spined skin overlying the scapula ...

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