Pharmacokinetics of gabapentin in domestic rabbits

Gabapentin is used to treat seizures, neuropathic pain, and anxiety. Currently, dosage recommendations for rabbits are extrapolated from other species. The objective of this study was to determine the pharmacokinetics of gabapentin after single, oral administration in domestic rabbits. A randomized, crossover study was performed in male (n = 3) and female (n = 3) rabbits after administration of either 25 or 50 mg/kg gabapentin orally. Plasma concentrations of gabapentin were measured at 0, 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 8, 12, 24, and 48 hours post-administration via liquid chromatography. Mean maximum plasma concentrations were 17.70 and 16.83 µg/mL for ...

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