Exposure to respirable silica contributes to lower airway inflammation in asthmatic horses

Respirable silica is associated with neutrophilic lower airway inflammation in horses and might contribute to asthma development

Respirable mineral particles can induce lower airway inflammation, but their role in horse asthma is unknown. This prospective observational study included 23 horses from an equine hospital population: 11 moderately affected (MEA), 7 severely asthmatic (SEA), and 5 control horses free from respiratory clinical signs. The quantity and quality of mineral particles found in bronchoalveolar lavage fluid (BALF) were characterized, with particular attention to silica content. Polarized light microscopy performed on cytospin slides identified intracellular birefringent particles as silica. Spectrometry-based analysis performed on whole BALF determined total mineral and silica percentage and concentration. Group-related differences in BALF mineral and silica load ...

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Antonio Maria Tardo Med Vet PhD Pneumology 28 October 2024

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Exposure to respirable silica contributes to lower airway inflammation in asthmatic horses

Scientific Publishing

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Exposure to respirable silica contributes to lower airway inflammation in asthmatic horses

Scientific Publishing